The hypoxic tumour microenvironment
نویسندگان
چکیده
منابع مشابه
Tumour microenvironment and angiogenesis
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A three-dimensional hybrid cellular automata (CA) model is developed to study the dynamic process of multicellular tumour spheroid (MTS) growth by introducing hypoxia as an important microenvironment factor which influences cell migration and cell phenotype expression. The model enables us to examine the effects of different hypoxic environments on the growth history of the MTS and to study the...
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tumour cells that lead to life-threatening malignancy. These studies have provided a comprehensive understanding of the role of oncogenes and tumour suppressor genes, as well as their associated signal transduction pathways, in cancer [1]. In recent years, it has become clear that a complete understanding of the many steps and processes that occur during cancer progression must include the resp...
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PURPOSE Retinoblastoma (RB) is a malignant tumor of infancy and childhood. Unfavorable therapeutic response is still a quest in many tumors, including retinoblastoma. Hypoxic tumor microenvironment is one of the factors that determine the therapeutic response in many tumors. The purpose of this study was to determine the presence of hypoxia and its related proteins; Hypoxia inducible factor-1α ...
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Tumor hypoxia is a serious and enduring problem for traditional solid tumor therapies. Many scientists continue to explore methods to improve or exploit tumor oxygenation; more recently, scientists have also focused on altering the molecular effects of hypoxia. These cellular responses to hypoxia and the resulting physiological effects, with a focus on angiogenesis, invasion/metastases, apoptos...
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ژورنال
عنوان ژورنال: Oncogenesis
سال: 2018
ISSN: 2157-9024
DOI: 10.1038/s41389-017-0011-9